The Center's broad mission is organized around five central themes: 1. To conduct research (basic, clinical, and applied) on the nature, development, etiology, and treatment of psychoactive substance use, misuse, abuse, and dependence by employing relevant biological, psychological, and sociocultural paradigms. 2. To develop, implement, and evaluate theory-driven prototypical clinical, prevention, and educational programs and services for appropriate target populations and constituent communities. 3. To facilitate the transfer and utilization of the Center's expertise by providing educational and training experiences for undergraduate, graduate, and post-graduate students and professionals in basic knowledge, the conduct of research, and the delivery of clinical and prevention services; and, to adapt and extend this expertise and knowledge to other individuals, groups, organizations, and agencies in the community. 4. To provide broad access to the knowledge base essential to students, researchers, clinicians, prevention and education specialists, and concerned others by identifying, organizing, and disseminating the fundamental empirical, theoretical, and practical literature of the field through a multi-formatted collection. 5. To assist agencies and organizations, public and private, charged with the responsibility to formulate policy in the analysis of issues related to psychoactive substance use, misuse, abuse, and dependence.